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ML335
CAS No. 825658-06-8
ML335( ML335 | ML-335 | ML 335 | TREK-1/2 Activator )
Catalog No. M17606 CAS No. 825658-06-8
ML335 is a selective activator of both TREK-1 and TREK-2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 54 | In Stock |
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| 2MG | 34 | In Stock |
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| 5MG | 54 | In Stock |
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| 10MG | 91 | In Stock |
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| 25MG | 187 | In Stock |
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| 50MG | 276 | In Stock |
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| 100MG | 415 | In Stock |
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| 200MG | 600 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameML335
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NoteResearch use only, not for human use.
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Brief DescriptionML335 is a selective activator of both TREK-1 and TREK-2.
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DescriptionML335 is a potent and selective TREK-1/2 Activator. ML335 is an agonist for OPRM1-OPRD1 heterdimerization with an EC50 of 403 nM, and selectivities vs. OPRM1, OPRD1, and HTR5A of 37, 2.7, and >99, respectively.
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In VitroXenopus oocyte two-electrode voltage-clamp measurements show that ML335 and ML402 activate K2P2.1 and K2P10.1 but not K2P4.1 (14.3±2.7?μM, K2P2.1-ML335; 13.7±7.0?μM, K2P2.1-ML402; 5.2±0.5?μM, K2P10.1-ML335; and 5.9±1.6?μM, K2P10.1-ML402). Swapping the Lys271 equivalent between K2P2.1 and K2P4.1 results in a clear phenotype reversal for ML335 and M402 activation. ML335 and ML402 activate K2P2.1 in HEK293 cells similar to their effects in Xenopus oocytes (5.2±0.8?μM and 5.9±1.6?μM for ML335 and ML402, respectively (n≥3)).
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In Vivo——
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SynonymsML335 | ML-335 | ML 335 | TREK-1/2 Activator
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorTREK-1| TREK-2
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Research Area——
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Indication——
Chemical Information
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CAS Number825658-06-8
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Formula Weight373.25
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Molecular FormulaC15H14Cl2N2O3S
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Purity>98% (HPLC)
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SolubilityDMSO : 155 mg/mL. 415.27 mM;
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SMILESCS(=O)(=O)Nc1ccc(cc1)C(=O)NCc1c(cc(cc1)Cl)Cl
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Chemical NameN-[(2,4-Dichlorophenyl)methyl]-4-(methanesulfonamido)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lolicato M, et al. K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature. 2017 Jul 20;547(7663):364-368.
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