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Ned 19
CAS No. 874374-25-1
Ned 19( —— )
Catalog No. M33037 CAS No. 874374-25-1
Ned 19, a selective membrane-permeant non-competitive antagonist of NAADP, strongly inhibits tumor growth, vascularization, and lung metastases in mice.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 149 | In Stock |
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| 2MG | 80 | In Stock |
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| 5MG | 132 | In Stock |
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| 10MG | 202 | In Stock |
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| 25MG | 341 | In Stock |
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| 50MG | 496 | In Stock |
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| 100MG | 706 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1423 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNed 19
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NoteResearch use only, not for human use.
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Brief DescriptionNed 19, a selective membrane-permeant non-competitive antagonist of NAADP, strongly inhibits tumor growth, vascularization, and lung metastases in mice.
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DescriptionNed 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca2+ signaling, with anIC50 of 65 nM. Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice.
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In VitroNed 19 (25-100 μM; 24-72?hours) reduces cell proliferation.Ned 19 (25-100 μM; 24-72?hours) reduces markedly the cell number.Ned 19 (25-100 μM; 24-72?hours) reduces the S phase percentage and increases of the G0/G1 phase percentage evaluated by cell cycle analysis. Ned 19 (25-100 μM; 24-72?hours) induces cell apoptosis a time-dependent manner. Ned 19 (25-100 μM; 24-72?hours) reduces expression of N-cadherin and increases expression of E-cadherin, affecting the cell migratory behavior. Cell Proliferation Assay Cell Line:B16 cells Concentration:25, 50, 100 μM Incubation Time:24, 48, 72?hours Result:Reduced cell proliferation.Cell Viability Assay Cell Line:B16 cells Concentration:25, 50, 100 μM Incubation Time:24, 48, 72?hours Result:Reduced markedly the cell number. Cell Cycle Analysis Cell Line:B16 cells Concentration:25, 50, 100 μM Incubation Time:24, 48, 72?hours Result:Reduced the S phase percentage and increased of the G0/G1 phase percentage.Apoptosis AnalysisCell Line:B16 cells Concentration:25, 50, 100 μM Incubation Time:24, 48, 72?hours Result:Induced cell apoptosis a time-dependent manner.Western Blot Analysis Cell Line:B16 cells Concentration:25, 50, 100 μM Incubation Time:24, 48, 72?hours Result:Reduced expression of N-cadherin and increased expression of E-cadherin.
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In VivoNed 19 (i.p.; 5?mg/Kg/every second day; 4 week) impaires severely tumor growth. Animal Model:Adult male C57BL/6 mice Dosage:5?mg/Kg Administration:I.p.; every second day; 4 week Result:Impaired severely tumor growth.
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Synonyms——
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number874374-25-1
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Formula Weight514.59
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Molecular FormulaC30H31FN4O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (242.91 mM; Ultrasonic )
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SMILESC(O)(=O)C1CC2=C(C(N1)C3=CC(CN4CCN(CC4)C5=C(F)C=CC=C5)=C(OC)C=C3)NC=6C2=CC=CC6
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rosen D, et al. Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonistNed-19 indicate two binding sites on the NAADP receptor. J Biol Chem. 2009 Dec 11;284(50):34930-4.?
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