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SB269970 HCl

CAS No. 261901-57-9

SB269970 HCl( SB-269970A )

Catalog No. M17459 CAS No. 261901-57-9

SB269970 HCl, a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SB269970 HCl
  • Note
    Research use only, not for human use.
  • Brief Description
    SB269970 HCl, a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors.
  • Description
    SB269970 HCl, a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors.
  • In Vitro
    ——
  • In Vivo
    SB269970 hydrochloride (SB-269970A) (3-30 mg/kg; i.p.; once) significantly blocks amphetamine and ketamine-induced hyperactivity. Animal Model:Male C57BL6/J miceDosage:3, 10, 30 mg/kg Administration:Intraperitoneal injection; onceResult:Significantly blocked amphetamine and ketamine-induced hyperactivity.
  • Synonyms
    SB-269970A
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    5-HT7
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    261901-57-9
  • Formula Weight
    388.95
  • Molecular Formula
    C18H28N2O3S·HCl
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 30 mg/mL; 77.13 mM
  • SMILES
    Cl.CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hagan JJ, et al. Br J Pharmacol, 2000, 130(3), 539-548.
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