Cart
sales@molnova.com
TRPM4-IN-2
CAS No. 667411-04-3
TRPM4-IN-2( —— )
Catalog No. M35537 CAS No. 667411-04-3
TRPM4-IN-2 (NBA), also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTRPM4-IN-2
-
NoteResearch use only, not for human use.
-
Brief DescriptionTRPM4-IN-2 (NBA), also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4).
-
DescriptionTRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer.
-
In VitroTRPM4-IN-2 (NBA) (50 μM; 0-500 s) blocks the endogenous TRPM4 currents in DU145.Cell Proliferation Assay Cell Line:DU145 Concentration:50 μM Incubation Time:0-500 s Result:Blocked 88 ± 9% of the endogenous TRPM4 currents at 50 μM.
-
In Vivo——
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetTRP/TRPV Channel
-
RecptorTRP/TRPV Channel
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number667411-04-3
-
Formula Weight355.77
-
Molecular FormulaC19H14ClNO4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (281.08 mM)
-
SMILESO(CC(NC1=C(C(O)=O)C=CC(Cl)=C1)=O)C=2C3=C(C=CC2)C=CC=C3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Borgstr?m A, et al. Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. J Mol Biol. 2021 Aug 20;433(17):166665.?
molnova catalog
related products
-
EIPA
EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.It is found that EIPA, benzamil, and phenamil rapidly and reversibly block Ca2+-activated TRPP3 channel activation at -50 mV, with IC50s of 143, 10.5, 1.1, and 0.14 μM, respectively.
-
L-R4W2
Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.
-
SAR7334
SAR7334 is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).
