CBP-IN-1( —— )

Catalog No. M22843 CAS No. 2222941-37-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

CBP-IN-1
Note

Research use only, not for human use.
Brief Description

CBP-IN-1 is a potent inhibitor of p300/CBP bromodomain.
Description

CBP-IN-1 is a potent inhibitor of p300/CBP bromodomain.
In Vitro

——
In Vivo

Animal Model:Noncastrated male athymic nude mice Dosage:10-30 mg/kg Administration:Oral gavage; at 10 or 20 mg/kg daily (QD) or at 30 mg/kg every other day (QOD) for 28 days Result:Affected tumor growth at 10 mg/kg daily, 20 mg/kg daily, and 30 mg/kg every other day.
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Epigenetic Reader Domain
Recptor

p300/CBP
Research Area

cancer
Indication

Haematological Malignancy|Acute Myeloid Leukemia|Non Hodgkin Lymphoma|Multiple Myeloma

CAS Number

2222941-37-7
Formula Weight

534.6
Molecular Formula

C30H32F2N4O3
Purity

>98% (HPLC)
Solubility

DMSO:100 mg/mL (187.06 mM; Need ultrasonic)
SMILES

O=C1N(C2=CC=C(F)C(F)=C2)[C@H](C3=NC4=CC(C5=C(C)ON=C5C)=CC=C4N3[C@H]6CC[C@H](OC)CC6)CCC1
Chemical Name

——

1. Neil Anthony Pegg, et al. Pharmaceutical compounds. WO2018073586A1.

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