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E6446 dihydrochloride

CAS No. 1345675-25-3

E6446 dihydrochloride( —— )

Catalog No. M17250 CAS No. 1345675-25-3

E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 236 In Stock
2MG 123 In Stock
5MG 205 In Stock
10MG 321 In Stock
25MG 619 In Stock
50MG 877 In Stock
100MG 1190 In Stock
200MG 1600 In Stock
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Biological Information

  • Product Name
    E6446 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
  • Description
    E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    p38 MAPK
  • Recptor
    TLR
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    1345675-25-3
  • Formula Weight
    522.51
  • Molecular Formula
    C27H37Cl2N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 7.6 mg/mL (14.55 mM)
  • SMILES
    c1(c2ccc(OCCCN3CCCC3)cc2)nc2ccc(OCCCN3CCCC3)cc2o1.Cl.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.
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