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Home - Products - MAPK/ERK Signaling - p38 MAPK - E6446 dihydrochloride

E6446 dihydrochloride

CAS No. 1345675-25-3

E6446 dihydrochloride( —— )

Catalog No. M17250 CAS No. 1345675-25-3

E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    E6446 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
  • Description
    E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    p38 MAPK
  • Recptor
    TLR
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    1345675-25-3
  • Formula Weight
    522.51
  • Molecular Formula
    C27H37Cl2N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 7.6 mg/mL (14.55 mM)
  • SMILES
    c1(c2ccc(OCCCN3CCCC3)cc2)nc2ccc(OCCCN3CCCC3)cc2o1.Cl.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.
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