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E6446 dihydrochloride
CAS No. 1345675-25-3
E6446 dihydrochloride( —— )
Catalog No. M17250 CAS No. 1345675-25-3
E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 236 | In Stock |
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| 2MG | 123 | In Stock |
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| 5MG | 205 | In Stock |
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| 10MG | 321 | In Stock |
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| 25MG | 619 | In Stock |
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| 50MG | 877 | In Stock |
|
| 100MG | 1190 | In Stock |
|
| 200MG | 1600 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameE6446 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionE6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
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DescriptionE6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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RecptorTLR
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1345675-25-3
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Formula Weight522.51
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Molecular FormulaC27H37Cl2N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 7.6 mg/mL (14.55 mM)
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SMILESc1(c2ccc(OCCCN3CCCC3)cc2)nc2ccc(OCCCN3CCCC3)cc2o1.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.
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