lavendustin A( Lavendustin A | RG 14355 | RG-14355 | RG14355. )

Catalog No. M17228 CAS No. 125697-92-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

lavendustin A
Note

Research use only, not for human use.
Brief Description

lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.
Description

Lavendustin A, also known as RG 14355, is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 11 nM). Lavendustin A shows cytotoxic effects on tumor cell lines. Lavendustin A enhances axon elongation in VHL gene-transfected neural stem cells.
In Vitro

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In Vivo

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Synonyms

Lavendustin A | RG 14355 | RG-14355 | RG14355.
Pathway

Endocrinology/Hormones
Target

CaMK
Recptor

EGFR
Research Area

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Indication

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CAS Number

125697-92-9
Formula Weight

381.38
Molecular Formula

C21H19NO6
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 250 mg/mL 655.51 mM
SMILES

O=C(O)c1cc(N(Cc2cc(O)ccc2O)Cc2ccccc2O)ccc1O
Chemical Name

5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid

1.Nam DH, et al. Synthesis and anticancer activity of chromone-based analogs of lavendustin A. Eur J Med Chem. 2010 Sep;45(9):4288-92

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