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KN-93 Phosphate B

CAS No. 1913269-12-1

KN-93 Phosphate B( —— )

Catalog No. M34125 CAS No. 1913269-12-1

KN-93 (Phosphate) can competitively block the binding of calmodulin to the corresponding kinase. It is a calcium/calmodulin-dependent kinase II (CaMKII) inhibitor with a Ki of 370 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 140 Get Quote
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Biological Information

  • Product Name
    KN-93 Phosphate B
  • Note
    Research use only, not for human use.
  • Brief Description
    KN-93 (Phosphate) can competitively block the binding of calmodulin to the corresponding kinase. It is a calcium/calmodulin-dependent kinase II (CaMKII) inhibitor with a Ki of 370 nM.
  • Description
    KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II, with Ki of 370 nM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    CaMK
  • Recptor
    CaMK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1913269-12-1
  • Formula Weight
    599.03
  • Molecular Formula
    C26H32ClN2O8PS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (166.94 mM; Ultrasonic )H2O : 50 mg/mL (83.47 mM; Ultrasonic)
  • SMILES
    OP(O)(O)=O.COc1ccc(cc1)S(=O)(=O)N(CCO)c1ccccc1CN(C)C\C=C\c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tombes RM, et al. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 1995 Sep;6(9):1063-70.?
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