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Azelastine
CAS No. 58581-89-8
Azelastine( —— )
Catalog No. M15153 CAS No. 58581-89-8
Azelastine is a potent, second-generation, selective, histamine antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 47 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAzelastine
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NoteResearch use only, not for human use.
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Brief DescriptionAzelastine is a potent, second-generation, selective, histamine antagonist.
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DescriptionAzelastine is a potent, second-generation, selective, histamine antagonist.
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In VitroAzelastine can significantly inhibit HNEpC proliferation, and therefore, be helpful in against airway remodeling.Cell Proliferation Assay Cell Line:Human nasal epithelial cells (HNEpC)Concentration:100 μM, 400 μM Incubation Time:21 days Result:Inhibited HNEpC growth.Western Blot Analysis Cell Line:Human nasal epithelial cells (HNEpC) Concentration:100 μM Incubation Time:7 days Result:Significantly up-regulated the H1R, M1R and M3R levels.
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In VivoAzelastine (4 mg/kg; p.o.; daily; for 8 weeks) significantly reduces blood glucose, HbA1c and serum alkaline phosphatase (ALP), osteocalcin and downregulates apolipoprotein B in diabetic hyperlipidemic rats model.Azelastine (4 mg/kg; p.o.; daily; for 8 weeks) improves the lipid profile (LDL-c decrease and HDL-c increase) in diabetic hyperlipidemic rats model.Azelastine (4 mg/kg; p.o.; daily; for 8 weeks) attenuates calcium deposition and aortic calcification in diabetic hyperlipidemic rats model. Animal Model:Male albino Wistar rats (150-170 g), diabetic hyperlipidemic rats modelDosage:4 mg/kg Administration:Oral administration, daily, for 8 weeks Result:Ameliorated aortic calcification and increased apolipoprotein A expression along with a decline in apolipoprotein B.
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Synonyms——
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorH1 receptor
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number58581-89-8
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Formula Weight381.9
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Molecular FormulaC22H24ClN3O
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Purity>98% (HPLC)
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SolubilitySoluble in DMSO
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SMILESCN1CCCC(CC1)N1N=C(CC2=CC=C(Cl)C=C2)C2=CC=CC=C2C1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Casale TB. J Allergy Clin Immunol. 1989 Apr;83(4):771-6.
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