KN-92 phosphate( —— )

Catalog No. M17153 CAS No. 1135280-28-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

KN-92 phosphate
Note

Research use only, not for human use.
Brief Description

KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII).
Description

KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
In Vitro

KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50μM; 24 hours) is ineffective in blocking cell growth.The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduced the expression of p53 and p21. Cell Viability Assay Cell Line:Human hepatic stellate cells (LX-2) Concentration:5-50 μM Incubation Time:24 hours Result:Ineffective in blocking cell growth.
In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

CaMK
Research Area

Others-Field
Indication

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1. Rokhlin OW, Guseva NV, Taghiyev AF et al. Cancer Biol Ther. 2010 Feb;9(3):224-35.

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