VU 0357017 hydrochloride( VU0357017, VU-0357017, VU 0357017, CID 25010775 )

Catalog No. M17152 CAS No. 1135242-13-5

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Product Name

VU 0357017 hydrochloride
Note

Research use only, not for human use.
Brief Description

VU 0357017 hydrochloride is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ± 172 nM; Pec50: 6.37 ± 0.15).
Description

VU0357017, also known as CID 25010775, is a subtype-selective M1 muscarinic acetylcholine allosteric agonist.
In Vitro

——
In Vivo

Animal Model:Male Sprague?Dawley rats (380-420 g) were pretreated with scopolamine Dosage:1, 3, 10 mg/kg Administration:A single i.p.Result:Produced a significant reversal of the scopolamine-induced deficits at a dose of 10 mg/kg.
Synonyms

VU0357017, VU-0357017, VU 0357017, CID 25010775
Pathway

Others
Target

Other Targets
Recptor

M1 mAChR
Research Area

Neurological Disease
Indication

——

CAS Number

1135242-13-5
Formula Weight

369.89
Molecular Formula

C18H28ClN3O3
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 33 mg/mL 89.22 mM
SMILES

CCOC(=O)N1CCC(CC1)NCCNC(=O)c1ccccc1C.Cl
Chemical Name

4-[[2-[(2-methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester, monohydrochloride

1.Digby GJ, et al. ACS Chem Neurosci. 2012 Dec 19;3(12):1025-36.

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