VGTI-A3-03( —— )

Catalog No. M17091 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

VGTI-A3-03
Note

Research use only, not for human use.
Brief Description

VGTI-A3-03 is a novel potent, highly virus-specific inhibitor of DENV replication with greatest activity against DENV serotype 2 (IC50=25 nM).
Description

VGTI-A3-03 is a novel potent, highly virus-specific inhibitor of DENV replication with greatest activity against DENV serotype 2 (IC50=25 nM), directly bind DENV capsid protein; also demonstrates some inhibitory activity against DENV1, DENV4, and WNV; does not inhibit viral RNA replication or secretion of viral particles, significantly diminishe secreted particles in treated cells, the binding pocket in the capsid molecule is at the dimerization interface; VGTI-A3-03 is incorporated into virus particles released from infected cells.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Microbiology/Virology
Target

Filovirus
Recptor

Filovirus
Research Area

——
Indication

——

CAS Number

——
Formula Weight

483.608
Molecular Formula

C26H21N5OS2
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

3-amino-6-phenyl-N-(4-phenylthiazol-2-yl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

1. Smith JL, et al. Antiviral Res. 2018 Apr 27;155:12-19.

Calculator

molnova catalog