ZIKV inhibitor K22( —— )

Catalog No. M13425 CAS No. 2141978-86-9

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Product Name

ZIKV inhibitor K22
Note

Research use only, not for human use.
Brief Description

ZIKV inhibitor K22 is a small molecule that exerts a potent antiviral activity against a broad range of coronaviruses by targeting membrane-bound viral RNA replication.
Description

ZIKV inhibitor K22 is a small molecule that exerts a potent antiviral activity against a broad range of coronaviruses by targeting membrane-bound viral RNA replication, effectively inhibits ZIKV with IC50 of 2.1 uM (48 h p.i); inhibits several members of the family Flaviviridae, blocks replication of ZIKV, yellow fever virus (YFV), Japanese encephalitis virus (JEV), West Nile virus (WNV), as well as to a certain extent, Usutu virus (USUV), Wesselsbron virus (WESSV), HCV and bovine viral diarrhea virus (BVDV) with IC50s <10 uM; act on early post-entry stages of coronavirus replication and to target membrane-bound viral RNA synthesis.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Microbiology/Virology
Target

Filovirus
Recptor

Filovirus
Research Area

——
Indication

——

CAS Number

2141978-86-9
Formula Weight

505.412
Molecular Formula

C27H25BrN2O3
Purity

>98% (HPLC)
Solubility

——
SMILES

C1CN(CCC1(C2=CC=C(C=C2)Br)O)C(=O)C(=CC3=CC=CC=C3)NC(=O)C4=CC=CC=C4
Chemical Name

(Z)-N-(3-(4-(4-bromophenyl)-4-hydroxypiperidin-1-yl)-3-oxo-1-phenylprop-1-en-2-yl)benzamide

1. García-Nicolás O, et al. Antimicrob Agents Chemother. 2018 Sep 4. pii: AAC.01206-18.

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