JNJ-1A( —— )

Catalog No. M17087 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

JNJ-1A
Note

Research use only, not for human use.
Brief Description

JNJ-1A is a novel Dengue virus (DENV) NS4B inhibitor that inhibits DENV-2 sub-genomic replicon at 0.7 μM.
Description

JNJ-1A is a novel Dengue virus (DENV) NS4B inhibitor that inhibits DENV-2 sub-genomic replicon at 0.7 μM, in the absence of cytotoxicity; shows equipotent antiviral activity against DENV serotypes 1, 2, and 4, induces mutation T108I in non-structural protein 4B (NS4B) in in vitro resistance selection experiments.
In Vitro

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In Vivo

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Synonyms

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Pathway

Microbiology/Virology
Target

Filovirus
Recptor

Filovirus
Research Area

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Indication

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CAS Number

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Formula Weight

761.942
Molecular Formula

C42H47N7O5S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

methyl ((S)-1-((S)-2-(5-(7-(2-((S)-1-(benzylsulfonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-9,10-dihydrophenanthren-2-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

1. Hernandez-Morales I, et al. Antiviral Res. 2017 Nov;147:149-158.

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