NTCP binder peptide WD1( —— )

Catalog No. M17088 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

NTCP binder peptide WD1
Note

Research use only, not for human use.
Brief Description

NTCP binder peptide WD1 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV.
Description

NTCP binder peptide WD1 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV, sodium taurocholate cotransporting polypeptide (NTCP, Kd=15 nM), reduces HBs antigen levels in culture supernatants; also inhibits cellular entry by the related hepatitis D virus (HDV), and is active against diverse strains of HBV (including clinically relevant nucleos(t)ide analog-resistant and vaccine escaping strains); exhibitsno inhibition of NTCP-mediated bile acid uptake in contrast to other NTCP-binding HBV entry inhibitors.
In Vitro

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In Vivo

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Synonyms

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Pathway

Microbiology/Virology
Target

HBV
Recptor

HBV
Research Area

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Indication

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CAS Number

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Formula Weight

1917.216
Molecular Formula

C95H125N19O22S
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

Cyclo-s-Ac-d-Tyr-Phe-Ile-Ile-ValMe-Gly(Me)-Thr-Trp-Thr-Trp-Thr-Trp-Ser-Cys-Thr-NH2

1. Passioura T, et al. Cell Chem Biol. 2018 Jul 19;25(7):906-915.e5.

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