GLP-26( GLP26 )

Catalog No. M13398 CAS No. 2133017-36-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

GLP-26
Note

Research use only, not for human use.
Brief Description

GLP-26 is a novel potent HBV capsid modulator that reduces secreted HBeAg in HepNTCPDL cells transfected with HBV wild type with EC50 of 0.7 uM.
Description

GLP-26 is a novel potent HBV capsid modulator that reduces secreted HBeAg in HepNTCPDL cells transfected with HBV wild type with EC50 of 0.7 uM; GLP26 is a potent inhibitor of cccDNA formation and HBeAg production against the mutant core T109I, demonstrates synergistic activity with ETV in the HepAD38 system, reducing HBV DNA replication.
In Vitro

Cell Viability Assay Cell Line:HepNTCP-DL cells Concentration:0.7-1.7 μM Incubation Time:3 days Result:Reduced secreted HBeAg in HepNTCP-DL cells.
In Vivo

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Synonyms

GLP26
Pathway

Microbiology/Virology
Target

HBV
Recptor

HBV
Research Area

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Indication

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CAS Number

2133017-36-2
Formula Weight

373.36
Molecular Formula

C19H17F2N3O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (334.81 mM)
SMILES

CC1=C(N(C(=C1C(=O)C(=O)NCC#C)C)C)C(=O)NC2=CC(=C(C=C2)F)F
Chemical Name

N-(3,4-difluorophenyl)-1,3,5-trimethyl-4-(2-oxo-2-(prop-2-yn-1-ylamino)acetyl)-1H-pyrrole-2-carboxamide