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AJM300

CAS No. 401905-67-7

AJM300( AJM 300 | AJM-300 )

Catalog No. M14377 CAS No. 401905-67-7

AJM300 (AJM 300, AJM-300) is a novel potent, selective, oraaly available alpha 4 integrin antagonist fortreatment of active ulcerative colitis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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1 mL x 10 mM in DMSO 161 In Stock
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Biological Information

  • Product Name
    AJM300
  • Note
    Research use only, not for human use.
  • Brief Description
    AJM300 (AJM 300, AJM-300) is a novel potent, selective, oraaly available alpha 4 integrin antagonist fortreatment of active ulcerative colitis.
  • Description
    AJM300 (AJM 300, AJM-300) is a novel potent, selective, oraaly available alpha 4 integrin antagonist fortreatment of active ulcerative colitis.Other Indication Phase 3 Clinical.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Mouse model of colitis induced by adoptive transfer of IL-10 deficient CD4+ T cells Dosage:Diet; 0.03, 0.1, 0.3 or 1% Administration:For 15 days Result:Had a histological improvement in epithelial cell hyperplasia, reduced inflammatory cell infiltration and a decrease in mucus production.Prevented an increase in the colon weight in a model of colitis induced by adoptive transfer of CD4+CD45RB high T cells.
  • Synonyms
    AJM 300 | AJM-300
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Integrin
  • Recptor
    Integrin
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    401905-67-7
  • Formula Weight
    569.439
  • Molecular Formula
    C28H26Cl2N4O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (175.61 mM)
  • SMILES
    O=C(OC)[C@H](CC1=CC=C(N2C(N(C)C3=C(C=C(N(C)C)C=C3)C2=O)=O)C=C1)NC(C4=C(Cl)C=CC=C4Cl)=O
  • Chemical Name
    methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Halland N, et al. ACS Med Chem Lett. 2014 Jan 10;5(2):193-8. 2. Park SC, et al. World J Gastroenterol. 2018 May 7;24(17):1868-1880. 3. Sugiura T, et al. J Crohns Colitis. 2013 Dec;7(11):e533-42. 4. Yoshimura N, et al. Gastroenterology. 2015 Dec;149(7):1775-1783.e2.
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