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Cyclo(RGDyK) trifluoroacetate

CAS No. 250612-42-1

Cyclo(RGDyK) trifluoroacetate ( Cyclic Arg-Gly-Asp-D-Tyr-Lys )

Catalog No. M13737 CAS No. 250612-42-1

Cyclo(RGDyK) (Cyclic Arg-Gly-Asp-D-Tyr-Lys) is a cyclic derivative of RGD, potent, selective αVβ3 integrin inhibitor with IC50 of 20 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cyclo(RGDyK) trifluoroacetate
  • Note
    Research use only, not for human use.
  • Brief Description
    Cyclo(RGDyK) (Cyclic Arg-Gly-Asp-D-Tyr-Lys) is a cyclic derivative of RGD, potent, selective αVβ3 integrin inhibitor with IC50 of 20 nM.
  • Description
    Cyclo(RGDyK) (Cyclic Arg-Gly-Asp-D-Tyr-Lys) is a cyclic derivative of RGD, potent, selective αVβ3 integrin inhibitor with IC50 of 20 nM; a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including αvβ3.(In Vitro):Cyclo(RGDyK) (c(RGDyK(SAA)) shows high affinity and selectivity for αVβ3 over αVβ5 (IC50=4000 nM) and αIIbβ3 (IC50=3000 nM).
  • In Vitro
    Cyclo(RGDyK) (c(RGDyK(SAA)) shows high affinity and selectivity for αVβ3 over αVβ5(IC50=4000 nM) and αIIbβ3 (IC50=3000 nM).
  • In Vivo
    ——
  • Synonyms
    Cyclic Arg-Gly-Asp-D-Tyr-Lys
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Integrin
  • Recptor
    αVβ3integrin
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    250612-42-1
  • Formula Weight
    847.72
  • Molecular Formula
    C31H43F6N9O12
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 94 mg/mL (110.9 mM)Water: 94 mg/mL (110.9 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=C(C=C2)O)CC(=O)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O
  • Chemical Name
    Cyclo(L-arginylglycyl-L-α-aspartyl-D-tyrosyl-L-lysyl), bis(trifluoroacetate) (salt) (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Haubner R, et al. J Nucl Med. 2001 Feb;42(2):326-36. 2. Chen Y, et al. PLoS One. 2016 Mar 1;11(3):e0149952. 3. Guo L, et al. J Nanosci Nanotechnol. 2014 Jul;14(7):4858-64.
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