Cart
sales@molnova.com
Ch-319
CAS No. ——
Ch-319( Ch319 )
Catalog No. M17011 CAS No. ——
Ch-319 (Ch319) is a triphenyltin (IV) carboxylate derivative that modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameCh-319
-
NoteResearch use only, not for human use.
-
Brief DescriptionCh-319 (Ch319) is a triphenyltin (IV) carboxylate derivative that modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer.
-
DescriptionCh-319 (Ch319) is a triphenyltin (IV) carboxylate derivative that modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer; reduces viability and induces cell cycle arrest associated with downregulation of PI3K and dephosphorylation of AKT and PRAS40 in PTEN-null PC3M and DU145 PCa cells at 250-500 nM; decreases tumor weights, reduces expression of androgen receptor, decreases phosphorylation of AKT and PRAS40 and increases FOXO3a in mice.
-
In Vitro——
-
In Vivo——
-
SynonymsCh319
-
PathwayCytoskeleton/Cell Adhesion Molecules
-
TargetAkt
-
RecptorAkt
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number——
-
Formula Weight604.293
-
Molecular FormulaC33H27NO3Sn
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Nametriphenylstannyl 2-(benzylcarbamoyl)benzoate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Durdana Waseem, et al. Abstract 688: Triphenylstannyl 2-(benzylcarbamoyl)benzoate (Ch-319) modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer. AACR.2018.
molnova catalog
related products
-
(2S)-2'-Methoxykurar...
(2S)-2'-Methoxykurarinone is isolated from the roots of Sophora flavescens. (2S)-2'-Methoxykurarinone has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects.
-
API-1
API-1 is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .
-
Sennidin B
Sennidin B stimulates glucose incorporation in rat adipocytes.
