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SJB3-019A
CAS No. ——
SJB3-019A( —— )
Catalog No. M17002 CAS No. ——
A novel potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 270 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSJB3-019A
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM.
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DescriptionA novel potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells; also increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity; triggers apoptosis in multiple myeloma cells via activation of caspase-3/8/9, degrades USP1 and downstream inhibitor of DNA-binding proteins as well as inhibits DNA repair via blockade of Fanconi anemia pathway and homologous recombination; downregulates multiple myeloma stem cell Notch-1, Notch-2, SOX-4, and SOX-2, and induces generation of more mature and differentiated plasma cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight276.2463
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Molecular FormulaC16H8N2O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILES——
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Chemical Name2-(pyridin-3-yl)naphtho[2,3-d]oxazole-4,9-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mistry H, et al. Mol Cancer Ther. 2013 Dec;12(12):2651-62.
2. Das DS, et al. Clin Cancer Res. 2017 Mar 7. doi: 10.1158/1078-0432.CCR-16-2692.
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SJB3-019A B
SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times more than SJB2-043, with IC50 of 0.0781 μM. SJB3-019A inhibits cell proliferation and causes cell apoptosis.
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