Ubiquitin Isopeptidase-IN-G5( NSC-144303 | NSC 144303 | NSC144303 )

Catalog No. M10333 CAS No. 108477-18-5

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Product Name

Ubiquitin Isopeptidase-IN-G5
Note

Research use only, not for human use.
Brief Description

A small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases.
Description

A small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases; induce a unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with up-regulation of the BH3-only protein Noxa, stabilization of the IAP antagonist Smac, but also the involvement of the death receptor pathway.
In Vitro

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In Vivo

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Synonyms

NSC-144303 | NSC 144303 | NSC144303
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

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Indication

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CAS Number

108477-18-5
Formula Weight

414.3887
Molecular Formula

C19H14N2O7S
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 31 mg/mL
SMILES

O=C(/C(C1)=C/C2=CC=C([N+]([O-])=O)C=C2)/C(CS1(=O)=O)=C/C3=CC=C([N+]([O-])=O)C=C3
Chemical Name

4H-Thiopyran-4-one, tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-, 1,1-dioxide

1. Aleo E, et al. Cancer Res. 2006 Sep 15;66(18):9235-44.

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