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PKCiota-IN-49
CAS No. ——
PKCiota-IN-49( —— )
Catalog No. M16982 CAS No. ——
PKCiota-IN-49 is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.8 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePKCiota-IN-49
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NoteResearch use only, not for human use.
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Brief DescriptionPKCiota-IN-49 is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.8 nM.
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DescriptionPKCiota-IN-49 is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.8 nM, >20-fold selectivity over PKC-α (IC50=71 nM) and PKC-β (IC50=350 nM); inhibits PKC-ι on the phosphorylation of substrate ECT2 in HCCLM3 cells with IC50 of 3.0 uM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetPKC
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RecptorPKC
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight395.466
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Molecular FormulaC24H21N5O
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name7-(5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridin-3-yl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kwiatkowski J, et al. J Med Chem. 2018 May 4. doi: 10.1021/acs.jmedchem.8b00060.
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