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AZD-9291 dimesylate

CAS No. ——

AZD-9291 dimesylate( Osimertinib dimesylate | Mereletinib dimesylate )

Catalog No. M16969 CAS No. ——

A potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZD-9291 dimesylate
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively.
  • Description
    A potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively; weak activity against wt EGFR (IC50=184 nM); inhibits signaling pathways and cellular growth in both EGFRm(+) and EGFRm(+)/T790M(+) mutant cell lines in vitro; exhibits tumor regression in EGFR-mutant tumor xenograft and transgenic models; orally active.Lung Cancer Approved.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Osimertinib dimesylate | Mereletinib dimesylate
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    691.8187
  • Molecular Formula
    C30H41N7O8S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 0.4 mg/mL
  • SMILES
    ——
  • Chemical Name
    2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-, methanesulfonate (1:2)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Finlay MR, et al. J Med Chem. 2014 Oct 23;57(20):8249-67. 2. Cross DA, et al. Cancer Discov. 2014 Sep;4(9):1046-61. 3. Eberlein CA, et al. Cancer Res. 2015 Jun 15;75(12):2489-500.
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