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BMS-690514
CAS No. 859853-30-8
BMS-690514( BMS690514 | BMS 690514 )
Catalog No. M16232 CAS No. 859853-30-8
A potent pan HER/VEGFR inhibitor with IC50 of 5/20/60/50 nM for EGFR/HER2/ERBB4/VEGFR2 respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 142 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBMS-690514
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NoteResearch use only, not for human use.
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Brief DescriptionA potent pan HER/VEGFR inhibitor with IC50 of 5/20/60/50 nM for EGFR/HER2/ERBB4/VEGFR2 respectively.
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DescriptionA potent pan HER/VEGFR inhibitor with IC50 of 5/20/60/50 nM for EGFR/HER2/ERBB4/VEGFR2 respectively; exerts antiproliferative and proapoptotic effects on NSCLC cell lines, with prominent efficacy on H1975 cells expressing the T790M mutation; induces G1 cell cycle arrest.Lung Cancer Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsBMS690514 | BMS 690514
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number859853-30-8
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Formula Weight368.4329
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Molecular FormulaC19H24N6O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO[C@@H]1CN(CC2=C3C(NC4=CC=CC(OC)=C4)=NC=NN3C=C2)CC[C@H]1N
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Chemical Name3-Piperidinol, 4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]-, (3R,4R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. de La Motte Rouge T, et al. Cancer Res. 2007 Jul 1;67(13):6253-62.
2. Wong TW, et al. Clin Cancer Res. 2011 Jun 15;17(12):4031-41.
3. Loriot Y, et al. Br J Cancer. 2010 Jul 27;103(3):347-53.
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