CR6086( CR 6086 | CR-6086 )

Catalog No. M16966 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

CR6086
Note

Research use only, not for human use.
Brief Description

CR6086 (CR-6086) is a potent, selective prostaglandin E2 receptor 4 (EP4) antagonist with Ki of 16.6 nM (hEP4 receptor).
Description

CR6086 (CR-6086) is a potent, selective prostaglandin E2 receptor 4 (EP4) antagonist with Ki of 16.6 nM (hEP4 receptor), inhibits PGE2-stimulated cAMP production with IC50 of 22 nM; reduces key cytokine players of RA (IL-6 and VEGF expression in macrophages, IL-23 release from dendritic cells, IL-17 release from Th17 cells) in models of human immune cells in culture; significantly improves all features of arthritis: severity, histology, inflammation and pain in CIA models of RA in rats and mice; CR6086 is better than the selective COX-2 inhibitor rofecoxib and at least as effective as the JAK inhibitor tofacitinib.Rheumatoid Arthritis Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

CR 6086 | CR-6086
Pathway

GPCR/G Protein
Target

Prostaglandin Receptor
Recptor

Prostaglandin Receptor
Research Area

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Indication

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CAS Number

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Formula Weight

494.49
Molecular Formula

C26H26F3N2NaO3
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

Sodium (R)-4-(1-(6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)cyclopropyl)benzoate

1. Caselli G, et al. Arthritis Res Ther. 2018 Mar 1;20(1):39.

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