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PF-04418948
CAS No. 1078166-57-0
PF-04418948( —— )
Catalog No. M10315 CAS No. 1078166-57-0
PF-04418948 (PF 04418948) is a novel potent and selective prostaglandin EP2 receptor antagonist; inhibits prostaglandin E(2)(PGE(2))-induced increase in cAMP in cells with a functional K(B) value of 1.8 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
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| 5MG | 57 | In Stock |
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| 10MG | 81 | In Stock |
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| 25MG | 176 | In Stock |
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| 50MG | 305 | In Stock |
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| 100MG | 337 | In Stock |
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Biological Information
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Product NamePF-04418948
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NoteResearch use only, not for human use.
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Brief DescriptionPF-04418948 (PF 04418948) is a novel potent and selective prostaglandin EP2 receptor antagonist; inhibits prostaglandin E(2)(PGE(2))-induced increase in cAMP in cells with a functional K(B) value of 1.8 nM.
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DescriptionPF-04418948 (PF 04418948) is a novel potent and selective prostaglandin EP2 receptor antagonist; inhibits prostaglandin E(2)(PGE(2))-induced increase in cAMP in cells with a functional K(B) value of 1.8 nM; attenuates the butaprost-induced cutaneous blood flow response in rats; orally active.(In Vitro):PF-04418948 (2 μM; 90 min) inhibits prostaglandin E2 (PGE2)-induced increase in cAMP.(In Vivo):PF-04418948 (oral gavage; 1, 3, and 10 mg/kg; once) attenuats the butaprost-induced cutaneous blood flow response.
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In VitroPF-04418948 (2 μM; 90 min) inhibits prostaglandin E2 (PGE2)-induced increase in cAMP. Cell Viability Assay Cell Line:CHO cells Concentration:2 μM Incubation Time:90 min Result:Inhibited prostaglandin E2 (PGE2)-induced increase in cAMP in cells expressing EP2 receptors with a functional KB value of 1.8 nM.
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In VivoPF-04418948 (oral gavage; 1, 3, and 10 mg/kg; once) attenuats the butaprost-induced cutaneous blood flow response. Animal Model:Sprague Dawley rats Dosage:1, 3, and 10 mg/kg Administration:Oral gavage; 1, 3, and 10 mg/kg; once Result:Reduced the peak and AUC butaprost-induced cutaneous blood flow response in a dose-dependent fashion.
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Synonyms——
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PathwayGPCR/G Protein
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TargetProstaglandin Receptor
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RecptorPGE2
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number1078166-57-0
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Formula Weight409.407
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Molecular FormulaC23H20FNO5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCOC1=CC2=C(C=C1)C=C(C=C2)OCC3(CN(C3)C(=O)C4=CC=C(C=C4)F)C(=O)O
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Chemical Name3-Azetidinecarboxylic acid, 1-(4-fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. af Forselles KJ, et al. Br J Pharmacol. 2011 Dec;164(7):1847-56.
2. Birrell MA, et al. Br J Pharmacol. 2013 Jan;168(1):129-38.
3. Kach J, et al. J Biol Chem. 2014 Mar 14;289(11):7505-13.
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