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Home - Products - Cell Cycle/DNA Damage - ATM/ATR - GSK 635416A

GSK 635416A

CAS No. 944729-29-7

GSK 635416A( GSK635416A )

Catalog No. M16767 CAS No. 944729-29-7

GSK 635416A is a novel ATM inhibitor with highly selective radiosensitizing activity, inhibits radiation induced phosphorylation of ATM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GSK 635416A
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK 635416A is a novel ATM inhibitor with highly selective radiosensitizing activity, inhibits radiation induced phosphorylation of ATM.
  • Description
    GSK 635416A is a novel ATM inhibitor with highly selective radiosensitizing activity, inhibits radiation induced phosphorylation of ATM; exhibits virtually no cytotoxicity in the absence of radiation and in normal fibroblast cells, enhances IR effect in radiosensitizing HNSCC cell lines but not in normal fibroblast BJ-ET cells in combined with olaparib.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GSK635416A
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    ATM/ATR
  • Recptor
    ATM/ATR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    944729-29-7
  • Formula Weight
    453.532
  • Molecular Formula
    C24H24FN3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    2-amino-5-(4-fluorophenyl)-N-methyl-3-(4-pyrrolidin-1-ylsulfonylphenyl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dohmen AJC, et al. Oncotarget. 2017 May 19;8(43):73925-73937.
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