CBP-93872( CBP93872 | CBP 93872 )

Catalog No. M15571 CAS No. 67427-51-4

A potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

CBP-93872
Note

Research use only, not for human use.
Brief Description

A potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint.
Description

A potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint; directly suppresses the growth of p53-mutated cancer cell lines with wild-type CDKN2A by eliciting G(1) arrest, but not CDKN2A-deleted and/or wild-type p53 lines; decreases phospho-cdc2 Y15 by inhibiting phosphorylation of Chk1; specifically inhibits DSB-mediated and Nbs1-dependent activation of ATR.
In Vitro

——
In Vivo

——
Synonyms

CBP93872 | CBP 93872
Pathway

Cell Cycle/DNA Damage
Target

ATM/ATR
Recptor

ATM/ATR
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

67427-51-4
Formula Weight

259.14
Molecular Formula

C10H15BrN2O
Purity

>98% (HPLC)
Solubility

——
SMILES

OC(CNC1=CC=C(C)C=C1Br)CN
Chemical Name

1-amino-3-((2-bromo-4-methylphenyl)amino)propan-2-ol

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Harada N, et al. Anticancer Drugs. 2011 Nov;22(10):986-94. 2. Hirokawa T, et al. Cancer Res. 2014 Jul 15;74(14):3880-9. 3. Iwata T, et al. PLoS One. 2017 May 30;12(5):e0178221.

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