Cart
sales@molnova.com
CBP-93872
CAS No. 67427-51-4
CBP-93872( CBP93872 | CBP 93872 )
Catalog No. M15571 CAS No. 67427-51-4
A potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameCBP-93872
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint.
-
DescriptionA potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint; directly suppresses the growth of p53-mutated cancer cell lines with wild-type CDKN2A by eliciting G(1) arrest, but not CDKN2A-deleted and/or wild-type p53 lines; decreases phospho-cdc2 Y15 by inhibiting phosphorylation of Chk1; specifically inhibits DSB-mediated and Nbs1-dependent activation of ATR.
-
In Vitro——
-
In Vivo——
-
SynonymsCBP93872 | CBP 93872
-
PathwayCell Cycle/DNA Damage
-
TargetATM/ATR
-
RecptorATM/ATR
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number67427-51-4
-
Formula Weight259.14
-
Molecular FormulaC10H15BrN2O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESOC(CNC1=CC=C(C)C=C1Br)CN
-
Chemical Name1-amino-3-((2-bromo-4-methylphenyl)amino)propan-2-ol
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Harada N, et al. Anticancer Drugs. 2011 Nov;22(10):986-94.
2. Hirokawa T, et al. Cancer Res. 2014 Jul 15;74(14):3880-9.
3. Iwata T, et al. PLoS One. 2017 May 30;12(5):e0178221.
molnova catalog
related products
-
BAY-1895344
BAY-1895344 is a potent, selective, orally active ATR inhibitor with low-nanomolar potency; potently inhibits the proliferation of a broad spectrum of human tumor cell lines with mean IC50 of 78 nM; inhibits hydroxyurea-induced H2AX phosphorylation, exhibits strong in vivo anti-tumor efficacy in monotherapy in a variety of xenograft models.Blood Cancer,Phase 1 Clinical
-
AZD-6738
AZD-6738 (AZD6738, Ceralasertib) is a potent and selective inhibitor of ATR with IC50 of 1 nM; shows no significant activity for ATM, DNA-PK and mTOR.
-
Arg-Gly-Asp TFA
RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to?integrins.
