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Simotinib
CAS No. 944258-89-3
Simotinib( SIM6802 | SIM-6802 )
Catalog No. M16764 CAS No. 944258-89-3
Simotinib (SIM-6802) is a novel potent EGFR inhibitor for treatment of NSCLC.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 258 | Get Quote |
|
| 50MG | 1269 | Get Quote |
|
| 100MG | 1791 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSimotinib
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NoteResearch use only, not for human use.
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Brief DescriptionSimotinib (SIM-6802) is a novel potent EGFR inhibitor for treatment of NSCLC.
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DescriptionSimotinib (SIM-6802) is a novel potent EGFR inhibitor for treatment of NSCLC.Lung Cancer Phase 1 Clinical.
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In VitroSimotinib inhibits in a dose-dependent manner EGFR and the growth of human A431 tumor cells with high expression of EGFR, with no significant activity on other investigated kinases.
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In VivoSimotinib has been shown to exert its antitumor activity by inhibiting EGFR phosphorylation in nude xenograft model.
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SynonymsSIM6802 | SIM-6802
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number944258-89-3
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Formula Weight500.95
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Molecular FormulaC25H26ClFN4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (249.53 mM)
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SMILESCOC1=C(OCCN2CC3(C4(OCCO4)C2)CC3)C=C(C(NC5=CC=C(F)C(Cl)=C5)=NC=N6)C6=C1
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Chemical NameN-(3-chloro-4-fluorophenyl)-6-(2-(5,8-dioxa-11-azadispiro(2.0.4.3)undec-11-yl)ethoxy)-7-methoxy-4-quinazolinamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Huang L, et al. Anticancer Drugs. 2016 Apr;27(4):300-11.
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