Cart
sales@molnova.com
PF 03716556
CAS No. 928774-43-0
PF 03716556( —— )
Catalog No. M16652 CAS No. 928774-43-0
PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 52 | In Stock |
|
| 10MG | 85 | In Stock |
|
| 25MG | 165 | In Stock |
|
| 50MG | 322 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePF 03716556
-
NoteResearch use only, not for human use.
-
Brief DescriptionPF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively.
-
DescriptionPF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.
-
In Vitro——
-
In VivoAnimal Model:Male Sprague-Dawley rats (250 -300 g) treated with Pentagastrin Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg Administration:Intraduodenal administration; once Result:Inhibited gastric acid secretion in a dose-dependent manner.
-
Synonyms——
-
PathwayEndocrinology/Hormones
-
TargetATPase
-
RecptorH+/K+-ATPase
-
Research AreaMetabolic Disease
-
Indication——
Chemical Information
-
CAS Number928774-43-0
-
Formula Weight394.48
-
Molecular FormulaC22H26N4O3
-
Purity>98% (HPLC)
-
SolubilityEthanol: 79 mg/mL (200.26 mM); DMSO: 79 mg/mL (200.26 mM)
-
SMILESCC1=C2[C@@H](CCOC2=CC=C1)NC3=CC(=CN4C3=NC(=C4)C)C(=O)N(C)CCO
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Mori, et al. J Pharmacol Exp Ther. 2009 Feb;328(2):671-9.
molnova catalog
related products
-
Tiludronate disodium
Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties.
-
Fenbufen
Fenbufen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives class.
-
Leminoprazole
Leminoprazole is an orally available H+,K(+)-ATPase inhibitor that protects gastric mucosal cells from various cellular damages.
