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NU7026
CAS No. 154447-35-5
NU7026( DNA-PK Inhibitor II | LY293646 )
Catalog No. M12190 CAS No. 154447-35-5
NU7026 is a potent DNA-PK inhibitor with IC50 of 0.23 μM in cell-free assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 30 | In Stock |
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| 5MG | 47 | In Stock |
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| 10MG | 77 | In Stock |
|
| 25MG | 159 | In Stock |
|
| 50MG | 314 | In Stock |
|
| 100MG | 426 | In Stock |
|
| 200MG | 599 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNU7026
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NoteResearch use only, not for human use.
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Brief DescriptionNU7026 is a potent DNA-PK inhibitor with IC50 of 0.23 μM in cell-free assays.
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DescriptionNU7026 is a potent DNA-PK inhibitor with IC50 of 0.23 μM in cell-free assays, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR.
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In VitroNU7026 (10 μM) potentiates ionizing radiation (IR) cytotoxicity [potentiation factor at 90% cell kill (PF90)=1.51±0.04] in exponentially growing DNA-PK proficient but not deficient cells. NU7026 synergistically sensitizes I83 cells to Chlorambucil (CLB) 3.5-fold.NU7026, a novel inhibitor of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK). At a dose of 10 μM, which is nontoxic to cells per se, a minimum NU7026 exposure of 4 h in combination with 3 Gy radiation is required for a significant radiosensitisation effect in CH1 human ovarian cancer cells.Solution in vitro: NU7026 is dissolved in anhydrous DMSO. NU7026 is added to cells to a final concentration of 0.25% DMSO (v/v).
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In VivoNU7026, a novel inhibitor of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK). Following intravenous administration to mice at 5 mg/kg, NU7026 underwent rapid plasma clearance (0.108 L/h) and this is largely attributed to extensive metabolism. Bioavailability following interperitoneal (i.p.) and p.o. administration at 20 mg/kg is 20 and 15%, respectively.Solution in vivo:NU7026 is formulated in 10% DMSO and 5% Tween 20 in saline (i.p. and p.o.) (Mice).NU7026 is formulated in 10% ethanol, 25% PEG 200 and 5% Tween 20 in saline (i.v.).
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SynonymsDNA-PK Inhibitor II | LY293646
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PathwayCell Cycle/DNA Damage
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TargetATM/ATR
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RecptorATM| ATR| DNA-PK| PI3K
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number154447-35-5
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Formula Weight281.31
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Molecular FormulaC17H15NO3
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Purity>98% (HPLC)
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SolubilityDMSO: 1 mg/mL (3.55 mM)
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SMILESO=C1C=C(N2CCOCC2)OC3=C1C=CC4=CC=CC=C43
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Chemical Name2-morpholino-4H-benzo[h]chromen-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Veuger SJ, et al. Y Res, 2003, 63(18), 6008-6015.
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