SCH-546738( SCH546738 )

Catalog No. M16517 CAS No. 906805-42-3

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Datasheet

HNMR

HPLC

MSDS

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Product Name

SCH-546738
Note

Research use only, not for human use.
Brief Description

SCH-546738 (SCH546738) is a potent, selective and non-competitive CXCR3 antagonist with binding Ki of 0.4 nM for human CXCR3.
Description

SCH-546738 (SCH546738) is a potent, selective and non-competitive CXCR3 antagonist with binding Ki of 0.4 nM for human CXCR3; displaces radiolabeled CXCL10 and CXCL11 from human CXCR3 with IC50 of 0.8-2 nM, potently and specifically inhibits CXCR3-mediated chemotaxis in human activated T cells with IC90 of 10 nM; attenuates the disease development in mouse collagen-induced arthritis model.
In Vitro

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In Vivo

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Synonyms

SCH546738
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

Inflammation/Immunology
Indication

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CAS Number

906805-42-3
Formula Weight

492.4445
Molecular Formula

C23H31Cl2N7O
Purity

>98% (HPLC)
Solubility

DMSO: 4.5 mg/mL (Need ultrasonic)
SMILES

O=C(C1=NC(Cl)=C(N2C[C@H](CC)N(C3CCN(CC4=CC=C(Cl)C=C4)CC3)CC2)N=C1N)N
Chemical Name

2-Pyrazinecarboxamide, 3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-

1. Jenh CH, et al. BMC Immunol. 2012 Jan 10;13:2. 2. Kim SH, et al. Bioorg Med Chem Lett. 2011 Dec 1;21(23):6982-6. (Compound 8a)

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