BI 6901( BI6901 )

Catalog No. M13172 CAS No. 2040401-92-9

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HNMR

HPLC

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Product Name

BI 6901
Note

Research use only, not for human use.
Brief Description

BI 6901 is a potent, selective CCR10 antagonist with Aequorin Ca2+ flux pIC50 of 9.0.
Description

BI 6901 is a potent, selective CCR10 antagonist with Aequorin Ca2+ flux pIC50 of 9.0, shows high selectivity over other GPCRs; inhibits the CCL27 dependent chemotaxis of Ba/F3 cells stably transfected with human CCR10 with pIC50 of 9.0, BI 6901 is efficacious in a murine model of DNFB contact hypersensitivity, inhibits DNFB stimulated inflammatory response in sensitized Balb-C mice.
In Vitro

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In Vivo

Animal Model:Balb-C mice with a DNFB model of contact hypersensitivity.Dosage:100 mg/kg Administration:Intraperitoneal?injection Result:Had a inhibitory effect on the DNFB stimulated inflammatory response in sensitized Balb-c mice.
Synonyms

BI6901
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

——
Indication

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CAS Number

2040401-92-9
Formula Weight

453.561
Molecular Formula

C23H27N5O3S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 160 mg/mL (352.76 mM)
SMILES

O=S(C1=CC=CC2=C1C=CN2)(N[C@H](CCN3C(C#N)=CC=C3)C(N4CCC(C)CC4)=O)=O
Chemical Name

N-[(2R)-4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-1H-indole-4-sulfonamide

1. Abeywardane A, et al. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283.

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