Cart
sales@molnova.com
POL3026
CAS No. 918660-21-6
POL3026( POL 3026 | POL-3026 )
Catalog No. M16597 CAS No. 918660-21-6
A highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.2 nM in Ca2+ flux assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePOL3026
-
NoteResearch use only, not for human use.
-
Brief DescriptionA highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.2 nM in Ca2+ flux assay.
-
DescriptionA highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.2 nM in Ca2+ flux assay; shows excellent plasma stability, high selectivity for CXCR4, favorable pharmacokinetic properties in vivo, has the potential to become a therapeutic compound for application in the treatment of HIV infections (as an entry inhibitor), cancer (for angiogenesis suppression and inhibition of metastasis), inflammation, and in stem cell transplant therapy.HIV Infection Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsPOL 3026 | POL-3026
-
PathwayGPCR/G Protein
-
TargetChemokine Receptor
-
RecptorChemokine Receptor
-
Research AreaInfection
-
IndicationHIV Infection
Chemical Information
-
CAS Number918660-21-6
-
Formula Weight——
-
Molecular Formula——
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical NameCyclo[3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-L-glutaminyl-L-lysyl-D-prolyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-L-arginylglycyl-D-prolyl-L-arginyl-L-arginyl], cyclic (2?1)-disulfide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. DeMarco SJ, et al. Bioorg Med Chem. 2006 Dec 15;14(24):8396-404.
2. Moncunill G, et al. Mol Pharmacol. 2008 Apr;73(4):1264-73.
3. Lesniak WG, et al. Mol Pharm. 2015 Mar 2;12(3):941-53.
molnova catalog
related products
-
INCB-3344
A potent, selective and orally bioavailable CCR2 antagonist with IC50 of 5.1 nM and 9.5 nM for hCCR2 and mCCR2, respectively.
-
K-777
K-777 is a potent and selective CCR4 antagonist that inhibits both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells with IC50 of 57 and 8.9 nM respectively.
-
BMS-681
A potent and orally bioavailable dual antagonist of CCR2 and CCR5 with binding IC50 of 0.7 nM and 2.4 nM, respectively.
