POL3026

Research use only, not for human use.

A highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.2 nM in Ca2+ flux assay.

A highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.2 nM in Ca2+ flux assay; shows excellent plasma stability, high selectivity for CXCR4, favorable pharmacokinetic properties in vivo, has the potential to become a therapeutic compound for application in the treatment of HIV infections (as an entry inhibitor), cancer (for angiogenesis suppression and inhibition of metastasis), inflammation, and in stem cell transplant therapy.HIV Infection Discontinued.

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POL 3026 | POL-3026

GPCR/G Protein

Chemokine Receptor

Chemokine Receptor

Infection

HIV Infection

918660-21-6

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>98% (HPLC)

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Cyclo[3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-L-glutaminyl-L-lysyl-D-prolyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-L-arginylglycyl-D-prolyl-L-arginyl-L-arginyl], cyclic (2?1)-disulfide

(-20℃)

With Ice Pack

≥ 2 years