NSC260594( NSC 260594 )

Catalog No. M16515 CAS No. 906718-66-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

NSC260594
Note

Research use only, not for human use.
Brief Description

NSC260594 (NSC 260594) is a specific inhibitor of HIV-1 RNA packaging.
Description

NSC260594 (NSC 260594) is a specific inhibitor of HIV-1 RNA packaging, which involves preventing the interaction of Gag with SL3 by stabilizing this small RNA stem-loop which then leads to stabilization of the global packaging signal region (psi or ψ); specifically blocks HIV-1 RNA encapsidation, binds to HIV-1 gRNA and exhibits potent antiviral activity; NSC260594 also is a small molecule inhibitor of the Escherichia coli condensin MukBEF, affects MukB directly.
In Vitro

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In Vivo

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Synonyms

NSC 260594
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

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Indication

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CAS Number

906718-66-9
Formula Weight

504.55
Molecular Formula

C29H24N6O3
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 3.33 mg/mL
SMILES

CN1C=CC(=NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)N=C4C=CN(C5=C4C=C(C=C5)[N+](=O)[O-])C)C=C1
Chemical Name

4-[(1-methyl-6-nitroquinolin-4-ylidene)amino]-N-[4-[(1-methylpyridin-4-ylidene)amino]phenyl]benzamide

1. Ingemarsdotter CK, et al. Retrovirology. 2018 Mar 14;15(1):25. 2. Zhao H, et al. ACS Infect Dis. 2018 Oct 22. doi: 10.1021/acsinfecdis.8b00222.

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