AMG1( AMG 1 | AMG-1 )

Catalog No. M16497 CAS No. 903591-53-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AMG1
Note

Research use only, not for human use.
Brief Description

A novel specific CRAC channel inhibitor that blocks function of effector.
Description

A novel specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo; potently suppresses SOCE following anti-CD3 stimulation in Th1, Th17 and iTreg cells at 100 nM, strongly reduces SOCE in Th1, Th17 and iTreg cells and significantly attenuates IFN-γ and IL-17 production in human CD4+ T cells with IC50 of 1792 nM and 57 nM, respectively; shows potential for Th1/Th17-mediated autoimmune diseases.
In Vitro

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In Vivo

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Synonyms

AMG 1 | AMG-1
Pathway

GPCR/G Protein
Target

Calcium Channel
Recptor

Calcium Channel
Research Area

——
Indication

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CAS Number

903591-53-7
Formula Weight

413.732
Molecular Formula

C18H9ClF5N3O
Purity

>98% (HPLC)
Solubility

——
SMILES

C1=CC(=C(C(=C1)F)C(=O)NC2=NC=C(N=C2)C3=C(C=CC(=C3)C(F)(F)F)Cl)F
Chemical Name

N-(5-(2-chloro-5-(trifluoromethyl)phenyl)-2-pyrazinyl)-2,6-difluorobenzamid

1. Kaufmann U, et al. J Immunol. 2016 Jan 15;196(2):573-85.

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