Cart
sales@molnova.com
AMG1
CAS No. 903591-53-7
AMG1( AMG 1 | AMG-1 )
Catalog No. M16497 CAS No. 903591-53-7
A novel specific CRAC channel inhibitor that blocks function of effector.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAMG1
-
NoteResearch use only, not for human use.
-
Brief DescriptionA novel specific CRAC channel inhibitor that blocks function of effector.
-
DescriptionA novel specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo; potently suppresses SOCE following anti-CD3 stimulation in Th1, Th17 and iTreg cells at 100 nM, strongly reduces SOCE in Th1, Th17 and iTreg cells and significantly attenuates IFN-γ and IL-17 production in human CD4+ T cells with IC50 of 1792 nM and 57 nM, respectively; shows potential for Th1/Th17-mediated autoimmune diseases.
-
In Vitro——
-
In Vivo——
-
SynonymsAMG 1 | AMG-1
-
PathwayGPCR/G Protein
-
TargetCalcium Channel
-
RecptorCalcium Channel
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number903591-53-7
-
Formula Weight413.732
-
Molecular FormulaC18H9ClF5N3O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC1=CC(=C(C(=C1)F)C(=O)NC2=NC=C(N=C2)C3=C(C=CC(=C3)C(F)(F)F)Cl)F
-
Chemical NameN-(5-(2-chloro-5-(trifluoromethyl)phenyl)-2-pyrazinyl)-2,6-difluorobenzamid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kaufmann U, et al. J Immunol. 2016 Jan 15;196(2):573-85.
molnova catalog
related products
-
Equilin
Equilin (7-Dehydroestrone) is a neurotrophic estrogenic steroid with vasodilatory activity that increases monocyte-endothelial adhesion through NF-κB signalling.
-
SR33805
SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)Acute treatment with SR33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes.?
-
Efonidipine hydrochl...
Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker.
