Cart
sales@molnova.com
Aloxistatin
CAS No. 88321-09-9
Aloxistatin( E64 d | Loxistatin | Rexostatine )
Catalog No. M16402 CAS No. 88321-09-9
An irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with the ability to inhibit calpain activity in intact platelets.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 46 | In Stock |
|
| 5MG | 72 | In Stock |
|
| 10MG | 110 | In Stock |
|
| 25MG | 178 | In Stock |
|
| 50MG | 332 | In Stock |
|
| 100MG | 494 | In Stock |
|
| 500MG | 1071 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAloxistatin
-
NoteResearch use only, not for human use.
-
Brief DescriptionAn irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with the ability to inhibit calpain activity in intact platelets.
-
DescriptionAn irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with the ability to inhibit calpain activity in intact platelets; reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B.Other Indication Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsE64 d | Loxistatin | Rexostatine
-
PathwayMetabolic Enzyme/Protease
-
TargetCathepsin
-
RecptorCysteineprotease
-
Research AreaOther Indications
-
IndicationOther Disease
Chemical Information
-
CAS Number88321-09-9
-
Formula Weight342.4305
-
Molecular FormulaC17H30N2O5
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 23 mg/mL
-
SMILESCCOC([C@@H]1[C@@H](C(N[C@H](C(NCCC(C)C)=O)CC(C)C)=O)O1)=O
-
Chemical Name2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ostrowski LE, et al. Cancer Res. 1986 Aug;46(8):4121-8.
2. Hook G, et al. J Alzheimers Dis. 2011;26(2):387-408.
3. McGowan EB, et al. Biochem Biophys Res Commun. 1989 Jan 31;158(2):432-5.
molnova catalog
related products
-
MIV-247
MIV-247 (MIV247)?is a potent, selective, orally active inhibitor of cathepsin S with Ki of 2.1 nM (human cathepsin S).
-
GSK 2793660
GSK 2793660(GSK2793660) is a potent, selective, irreversible and orally bioavailable cathepsin C inhibitor.
-
ONO-5334
A potent, selective, orally active inhibitor of cathepsin K with Ki of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively.
