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Aloxistatin
CAS No. 88321-09-9
Aloxistatin( E64 d | Loxistatin | Rexostatine )
Catalog No. M16402 CAS No. 88321-09-9
An irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with the ability to inhibit calpain activity in intact platelets.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 61 | In Stock |
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| 2MG | 48 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 116 | In Stock |
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| 25MG | 188 | In Stock |
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| 50MG | 343 | In Stock |
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| 100MG | 511 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1107 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAloxistatin
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NoteResearch use only, not for human use.
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Brief DescriptionAn irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with the ability to inhibit calpain activity in intact platelets.
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DescriptionAn irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with the ability to inhibit calpain activity in intact platelets; reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B.Other Indication Discontinued.
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In Vitro——
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In Vivo——
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SynonymsE64 d | Loxistatin | Rexostatine
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PathwayMetabolic Enzyme/Protease
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TargetCathepsin
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RecptorCysteineprotease
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number88321-09-9
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Formula Weight342.4305
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Molecular FormulaC17H30N2O5
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 23 mg/mL
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SMILESCCOC([C@@H]1[C@@H](C(N[C@H](C(NCCC(C)C)=O)CC(C)C)=O)O1)=O
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Chemical Name2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ostrowski LE, et al. Cancer Res. 1986 Aug;46(8):4121-8.
2. Hook G, et al. J Alzheimers Dis. 2011;26(2):387-408.
3. McGowan EB, et al. Biochem Biophys Res Commun. 1989 Jan 31;158(2):432-5.
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