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GSK 2793660
CAS No. 1613458-79-9
GSK 2793660( GSK2793660 | GSK-2793660 )
Catalog No. M12343 CAS No. 1613458-79-9
GSK 2793660(GSK2793660) is a potent, selective, irreversible and orally bioavailable cathepsin C inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | In Stock |
|
| 50MG | 1782 | In Stock |
|
| 100MG | 2250 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK 2793660
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NoteResearch use only, not for human use.
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Brief DescriptionGSK 2793660(GSK2793660) is a potent, selective, irreversible and orally bioavailable cathepsin C inhibitor.
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DescriptionGSK 2793660(GSK2793660) is a potent, selective, irreversible and orally bioavailable cathepsin C inhibitor, but not the activity of downstream neutrophil serine proteases, for the treatment of cystic fibrosis, non-cystic fibrosis bronchiectasis, ANCA-associated vasculitis and bronchiectasis.Other Indication Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsGSK2793660 | GSK-2793660
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PathwayMetabolic Enzyme/Protease
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TargetCathepsin
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RecptorCathepsin
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number1613458-79-9
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Formula Weight421.966
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Molecular FormulaC22H32ClN3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1(N)CCOCC1)N[C@@H](CC(C)C)/C=C/C(N2CCC3=C2C=CC=C3)=O.[H]Cl
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Chemical Name(S,E)-4-amino-N-(1-(indolin-1-yl)-6-methyl-1-oxohept-2-en-4-yl)tetrahydro-2H-pyran-4-carboxamide hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Miller BE, et al. Br J Clin Pharmacol. 2017 Dec;83(12):2813-2820.
2. Szcze?niak P, et al. J Org Chem. 2016 Feb 5;81(3):1057-74.
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