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Odanacatib
CAS No. 603139-19-1
Odanacatib( MK-0822 | MK 0822 | MK0822 )
Catalog No. M15252 CAS No. 603139-19-1
A potent, selective, reversible and orally active cathepsin K inhibitor with IC50 of 0.2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 52 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 117 | In Stock |
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| 50MG | 184 | In Stock |
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| 100MG | 346 | In Stock |
|
| 200MG | 639 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameOdanacatib
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, reversible and orally active cathepsin K inhibitor with IC50 of 0.2 nM.
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DescriptionA potent, selective, reversible and orally active cathepsin K inhibitor with IC50 of 0.2 nM; displays >300-fold selectivity over cathepsin B, L, S, F, and V; demonstrates the potentiation for the treatment of osteoporosis and other skeletal disorders associated with excessive bone remodeling.Osteoporosis Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsMK-0822 | MK 0822 | MK0822
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PathwayMetabolic Enzyme/Protease
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TargetCathepsin
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RecptorCathepsinK(human)|CathepsinK(rabbit)
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Research AreaMetabolic Disease
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IndicationOsteoporosis
Chemical Information
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CAS Number603139-19-1
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Formula Weight525.5588
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Molecular FormulaC25H27F4N3O3S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥25 mg/mL
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SMILESCC(C)(F)C[C@H](N[C@@H](C1=CC=C(C2=CC=C(S(=O)(C)=O)C=C2)C=C1)C(F)(F)F)C(NC3(C#N)CC3)=O
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Chemical NamePentanamide, N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]-, (2S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gauthier JY, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):923-8.
2. Kumar V, et al. Mol Pharm. 2009 Jul-Aug;6(4):1118-24.
3. Eisman JA, et al. J Bone Miner Res. 2011 Feb;26(2):242-51.
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