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AZD-1305
CAS No. 872045-91-5
AZD-1305( AZD1305 )
Catalog No. M16340 CAS No. 872045-91-5
AZD-1305 is a novel antiarrhythmic agent that predominantly blocks the rapid component of Ikr.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 238 | In Stock |
|
| 5MG | 212 | In Stock |
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| 10MG | 306 | In Stock |
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| 25MG | 471 | In Stock |
|
| 50MG | 643 | In Stock |
|
| 100MG | 879 | In Stock |
|
| 200MG | 1190 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD-1305
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NoteResearch use only, not for human use.
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Brief DescriptionAZD-1305 is a novel antiarrhythmic agent that predominantly blocks the rapid component of Ikr.
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DescriptionAZD-1305 is a novel antiarrhythmic agent that predominantly blocks the rapid component of IKr, the L-type calcium current, and the inward sodium current in mammalian cells and ventricular cardiomyocytes; significantly prolongs action potential duration and reduces excitability at 0.1-10 uM in dogs, effectively prevents induction of persistent acetylcholine-mediated atrial fibrillation (AF) in vivo.Heart Arrhythmia Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsAZD1305
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorSodium Channel
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Research AreaCardiovascular Disease
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IndicationHeart Arrhythmia
Chemical Information
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CAS Number872045-91-5
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Formula Weight434.512
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Molecular FormulaC22H31FN4O4
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)(C)OC(=O)NCCN1C[C@@H]2CN(C[C@H](C1)O2)CCOc3ccc(cc3F)C#N
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Chemical Name(2-(7-(2-(4-Cyano-2-fluorophenoxy)ethyl)-9-oxa-3,7-diazabicyclo(3.3.1)non-3-yl)ethyl)carbamic acid tert-butyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sicouri S, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):255-9.
2. Burashnikov A, et al. J Cardiovasc Pharmacol. 2010 Jul;56(1):80-90.
3. Johnson DM, et al. Circ Arrhythm Electrophysiol. 2012 Feb;5(1):201-9.
4. Geller JC, et al. J Clin Pharmacol. 2009 Mar;49(3):312-22.
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