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Azilsartan medoxomil
CAS No. 863031-21-4
Azilsartan medoxomil( TAK 491 | TAK-491 | TAK491 )
Catalog No. M16246 CAS No. 863031-21-4
A specific and potent angiotensin II type 1 receptor (AT1) antagonist with IC50 of 2.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
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| 5MG | 72 | In Stock |
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| 10MG | 110 | In Stock |
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| 25MG | 200 | In Stock |
|
| 50MG | 335 | In Stock |
|
| 100MG | 494 | In Stock |
|
| 500MG | 1053 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAzilsartan medoxomil
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NoteResearch use only, not for human use.
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Brief DescriptionA specific and potent angiotensin II type 1 receptor (AT1) antagonist with IC50 of 2.6 nM.
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DescriptionA specific and potent angiotensin II type 1 receptor (AT1) antagonist with IC50 of 2.6 nM, used in the treatment of adults with essential hypertension. Hypertension Approved.
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In Vitro——
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In VivoAnimal Model:Rats Dosage:0.03-10 mg/kg Administration:oral gavage, once a day for 4 days Result:Reduced myocardial infarct size.Increased calcium-dependent nitric oxide synthase activity.Increased Akt, ERK 1/2 and eNOS phosphorylation and inhibited BAX activation.
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SynonymsTAK 491 | TAK-491 | TAK491
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PathwayGPCR/G Protein
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TargetAngiotensin Receptor
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RecptorAT1receptor
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Research AreaCardiovascular Disease
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IndicationHypertension
Chemical Information
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CAS Number863031-21-4
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Formula Weight568.5336
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Molecular FormulaC30H24N4O8
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)N5)C(=O)OCC6=C(OC(=O)O6)C
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Chemical Name1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. French C, et al. J Cardiovasc Pharmacol. 2011 Aug;58(2):143-8.
2. Kusumoto K, et al. Eur J Pharmacol. 2011 Nov 1;669(1-3):84-93.
3. B?nner G, et al. J Hum Hypertens. 2013 Aug;27(8):479-86.
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