PF-00610355( PF-610355 )

Catalog No. M16243 CAS No. 862541-45-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-00610355
Note

Research use only, not for human use.
Brief Description

PF-00610355 (PF 610355) is a potent, selective, and long-acting β2-adrenoreceptor agonist with EC50 of 0.26 nM.
Description

PF-00610355 (PF 610355) is a potent, selective, and long-acting β2-adrenoreceptor agonist with EC50 of 0.26 nM; displays 220-fold selectivity over β1; exhibits potential as inhaled ultra-long-acting bronchodilators for the treatment of asthma and chronic obstructive pulmonary disease.Asthma Phase 2 Discontinued.
In Vitro

——
In Vivo

PF-610355 is a long-acting (once daily) inhaled β2-adrenoreceptor agonist. PF-610355 has low oral bioavailability due to poor absorption through the gut lumen and high first pass metabolism and warranted further progression. PF-610355 has a short half-life (Clint = 33 (μL/min)/mg) that suggested an unbound intrinsic clearance of >10000 (mL/min)/kg. PF-610355 exhibits an ideal pharmacokinetic profile for an inhaled agent.
Synonyms

PF-610355
Pathway

GPCR/G Protein
Target

Adrenergic Receptor
Recptor

Adrenergic Receptor
Research Area

Inflammation/Immunology
Indication

Asthma

CAS Number

862541-45-5
Formula Weight

617.76
Molecular Formula

C34H39N3O6S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NCC1=CC(C2=CC=C(O)C=C2)=CC=C1)CC3=CC=CC(CC(C)(NC[C@H](O)C4=CC=C(O)C(NS(=O)(C)=O)=C4)C)=C3
Chemical Name

N-((4'-hydroxy(1,1'-biphenyl)-3-yl)methyl)-3-(2-(((2R)-2-hydroxy-2-(4-hydroxy-3-((methylsulfonyl)amino)phenyl)ethyl)amino)-2-methylpropyl)-benzeneacetamide

1. Glossop PA, et al. J Med Chem. 2010 Sep 23;53(18):6640-52. 2. Diderichsen PM, et al. Br J Clin Pharmacol. 2013 Nov;76(5):752-62.

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