Apraclonidine hydrochloride( —— )

Catalog No. M33725 CAS No. 73218-79-8

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Product Name

Apraclonidine hydrochloride
Note

Research use only, not for human use.
Brief Description

Apraclonidine hydrochloride (ALO 2145) is an α2-adrenergic agonist and a weak α-1 adrenergic receptor agonist.
Description

Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid.
In Vitro

Apraclonidine hydrochloride (ALO 2145) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects.
In Vivo

Apraclonidine hydrochloride (ALO 2145) is effective in animal models of elevated IOP as well as glaucoma in humans. The ocular hypotensive effects of Apraclonidine are usually attributed to reduced aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery.Apraclonidine (1.15%, single instillation) inhibits 98% of PGE2-induced aqueous flare elevationy.Animal Model:male rabbits.Dosage:1.15% Administration:Apraclonidine (1.15%, single instillation)Result:Inhibited PGE2-induced elevation of aqueous flare in pigmented rabbits.
Synonyms

——
Pathway

GPCR/G Protein
Target

Adrenergic Receptor
Recptor

Adrenergic Receptor
Research Area

——
Indication

——

CAS Number

73218-79-8
Formula Weight

281.57
Molecular Formula

C9H11Cl3N4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (443.94 mM; Ultrasonic )H2O : ≥ 12.5 mg/mL (44.39 mM)
SMILES

Cl.Nc1cc(Cl)c(NC2=NCCN2)c(Cl)c1
Chemical Name

——

1. Wijemanne S, et al. Apraclonidine in the treatment of ptosis. J Neurol Sci. 2017;376:129‐132.?

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