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Naronapride

CAS No. 860174-12-5

Naronapride( ATI-7505 )

Catalog No. M16233 CAS No. 860174-12-5

Naronapride (ATI-7505) is a potent, selective and orally active 5-HT4 receptor agonist with Ki of 1.4 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Naronapride
  • Note
    Research use only, not for human use.
  • Brief Description
    Naronapride (ATI-7505) is a potent, selective and orally active 5-HT4 receptor agonist with Ki of 1.4 nM.
  • Description
    Naronapride (ATI-7505) is a potent, selective and orally active 5-HT4 receptor agonist with Ki of 1.4 nM; displays negligible affinity for Kv11.1 channels (Ki=24,500 nM), and no effect on cardiac repolarization; shows potential for treatment of gastrointestinal motility disorders.Other Indication Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ATI-7505
  • Pathway
    GPCR/G Protein
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    860174-12-5
  • Formula Weight
    537.098
  • Molecular Formula
    C27H41ClN4O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (186.19 mM)
  • SMILES
    O=C(O[C@H]1CN2CCC1CC2)CCCCCN3C[C@H](OC)[C@H](NC(C4=CC(Cl)=C(N)C=C4OC)=O)CC3
  • Chemical Name
    [(3R)-1-azabicyclo[2.2.2]octan-3-yl] 6-[(3S,4R)-4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-3-methoxypiperidin-1-yl]hexanoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Manabe N, et al. Expert Opin Investig Drugs. 2010 Jun;19(6):765-75. 2. Bowersox SS, et al. Drug Metab Dispos. 2011 Jul;39(7):1170-80. 3. Hoffman JM, et al. Gastroenterology. 2012 Apr;142(4):844-854.e4. 4. Camilleri M, et al. Neurogastroenterol Motil. 2007 Jan;19(1):30-8.
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