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SB-215505
CAS No. 162100-15-4
SB-215505( —— )
Catalog No. M34411 CAS No. 162100-15-4
SB-215505 is a subtype-selective 5-HT2B receptor antagonist that inhibits 5-HT2B, 5-HT2A, and 5-HT2C.SB-215505 can be used to study prostate cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 347 | Get Quote |
|
| 5MG | 541 | Get Quote |
|
| 10MG | 753 | Get Quote |
|
| 25MG | 1086 | Get Quote |
|
| 50MG | 1500 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSB-215505
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NoteResearch use only, not for human use.
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Brief DescriptionSB-215505 is a subtype-selective 5-HT2B receptor antagonist that inhibits 5-HT2B, 5-HT2A, and 5-HT2C.SB-215505 can be used to study prostate cancer.
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DescriptionSB-215505 is a potent and subtype-selective 5-HT2B receptor antagonist with pKi values of 8.3, 6.77, 7.66 for 5-HT2B, 5-HT2A, 5-HT2C, respectively. SB-215505 increases wakefulness and motor activity in rats.
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In VitroSB-215505 is 30 fold selective for the 5-HT2B over the 5-HT2A receptor, and only marginally selective over the 5-HT2C receptor.
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In VivoSB-215505 (0.1-1.0 mg/kg; i.p.; two doses) dose-dependently increases wakefulness (W) and decreases IS, PS, SWS-2.Animal Model:Male Sprague-Dawley rats weighing 230-260 g Dosage:0.1, 0.3 and 1.0 mg/kg Administration:IP; two doses (4 days between two doses) Result:Dose-dependently increased wakefulness (W) and decreased intermediate stage of sleep (IS), paradoxical sleep (PS), SWS-2.
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Synonyms——
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PathwayGPCR/G Protein
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number162100-15-4
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Formula Weight337.8
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Molecular FormulaC19H16ClN3O
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Purity>98% (HPLC)
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Solubility——
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SMILESCc1cc2CCN(C(=O)Nc3cccc4ncccc34)c2cc1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. C Reavill, et al. Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br J Pharmacol. 1999 Feb;126(3):572-4.?
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