LMD-A( CCR8 antagonist LMD-A )

Catalog No. M16174 CAS No. 850330-77-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LMD-A
Note

Research use only, not for human use.
Brief Description

LMD-A (CCR8 antagonist LMD-A) is a highly potent, small molecule antagonist of chemokine receptor CCR8 with EC50 of 2.5 nM.
Description

LMD-A (CCR8 antagonist LMD-A) is a highly potent, small molecule antagonist of chemokine receptor CCR8 with EC50 of 2.5 nM; inhibits 10 nM CCL1-induced activation of CCR8 with EC50 of 12 nM, inhibits 4DE4 cells cell migration induced by 3 nM CCL1 with EC50 of 0.58 nM.
In Vitro

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In Vivo

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Synonyms

CCR8 antagonist LMD-A
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

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Indication

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CAS Number

850330-77-7
Formula Weight

508.637
Molecular Formula

C27H32N4O4S
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(NC1=C2C=CC=C(S(=O)(N[C@H]3[C@H](C)CN(C([C@H](C)N)=O)CC3)=O)C2=CC=C1)C4=CC=CC=C4C
Chemical Name

N-(5-(N-((3R,4R)-1-(L-alanyl)-3-methylpiperidin-4-yl)sulfamoyl)naphthalen-1-yl)-2-methylbenzamide

1. Rummel PC, et al. Br J Pharmacol. 2012 Nov;167(6):1206-17. 2. Barington L, et al. J Biol Chem. 2016 Jul 29;291(31):16208-20.

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