AMD-070 hydrochloride

Research use only, not for human use.

A potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay.

A potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay; displays no significant activity (IC50>10 uM) for a series of other closely GPCRs (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2); inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with IC50 of 2 nM and 26 nM, respectively, with noncytotoxic to cells (>23 uM); exhibits good PK profiles and excellent oral bioavailability; also inhibits CXCR4/SDF-1-mediated events in ALL cancer cells and transplant models.HIV Infection Phase 3 Clinical.

——

——

AMD-11070 hydrochloride

GPCR/G Protein

Chemokine Receptor

Chemokine Receptor

Infection

HIV Infection

880549-30-4

458.8554

C21H30Cl3N5

>98% (HPLC)

10 mM in DMSO

C1CC(C2=C(C1)C=CC=N2)N(CCCCN)CC3=NC4=CC=CC=C4N3.Cl

1,4-Butanediamine, N1-(1H-benzimidazol-2-ylmethyl)-N1-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-, hydrochloride (1:1)

(-20℃)

With Ice Pack

≥ 2 years