K-777( K 777 | K777 )

Catalog No. M15857 CAS No. 749860-43-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

K-777
Note

Research use only, not for human use.
Brief Description

K-777 is a potent and selective CCR4 antagonist that inhibits both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells with IC50 of 57 and 8.9 nM respectively.
Description

K-777 is a potent and selective CCR4 antagonist that inhibits both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells with IC50 of 57 and 8.9 nM respectively; induces CCR4 internalization, reduces cell surface CCR4.
In Vitro

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In Vivo

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Synonyms

K 777 | K777
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

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Indication

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CAS Number

749860-43-3
Formula Weight

641.5
Molecular Formula

C28H32F4IN5
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

1-(1-(4-((2,4-difluorobenzyl)amino)-5-(2,4-difluorophenyl)pyrimidin-2-yl)piperidin-4-yl)-1-methylpiperidin-1-ium

1. Sato T, et al. Pharmacology. 2013;91(5-6):305-13. 2. Solari R, et al. Eur J Pharmacol. 2015 Sep 15;763(Pt B):169-77.

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