Mecamylamine hydrochloride ( Inversine )

Catalog No. M16067 CAS No. 826-39-1

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HNMR

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Product Name

Mecamylamine hydrochloride
Note

Research use only, not for human use.
Brief Description

A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier.
Description

A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
In Vitro

Western Blot Analysis Cell Line:SCG neurons Concentration:10 μM Incubation Time:48 h Result:Reduced the nicotine-facilitated increase in ERK1/2.
In Vivo

Animal Model:Choroidal neovascularization (CNV) mice model Dosage:50 mg/kg/day, 2 days Administration:Subcutaneous pumps implanted beneath the skin of the back, 200 μL and mean pumping rate of 0.5 μL/h. Result: Suppressed the development of CNV at Bruch’s membrane rupture sites in the absence of nicotine.Animal Model:C57BL/6J mice Dosage:0.5-1 mg/kg Administration:Intraperitoneal injection Result:Had no effect in β2 knockout mice and α7 knockout mice, but decreased immobility time in wildtype littermates in the FST.
Synonyms

Inversine
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

nAChR
Research Area

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Indication

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1. Struthers AM, et al. Pharmacol Biochem Behav. 2009 Dec;94(2):319-28.

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