Diammonium Glycyrrhizinate

Research use only, not for human use.

Diammonium glycyrrhizinate is a widely used anti-inflammatory agent isolated from the licorice root.

Diammonium glycyrrhizinate is a widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inhibits 11-beta-hydroxysteroid dehydrogenases and other enzymes involved in the metabolism of corticosteroids. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.

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Metabolic Enzyme/Protease

Dehydrogenase

11-beta-hydroxysteroid dehydrogenase

Other Indications

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79165-06-3

857

C42H62O16·2H3N

>98% (HPLC)

Soluble in Water

C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)O)O)O)O)C)(C)C(=O)O.N.N

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(-20℃)

With Ice Pack

≥ 2 years